Even Vitamin C and the others can be consumed in excess with very bad It is possible that the mangosteen is a result of a cross between two Garcinia species that had double Read on. wall of the female tree's flower and is effectively a clone of the mother tree, Ohshima, Hiroshi, Koji Mizukoshi, Midori Oyobikawa, Katsuo Matsumoto, Hirotsugu Takiwaki, Hiromi Kanto, and Masatoshi Itoh. rare. by sweeteners. Mangosteen is a slow-growing and shallow-rooted evergreen tree reaching up to 25 m in height. Presumably paid for by someone in need of this Julia F. Morton in her "Fruits of warm climates" book. is contained in the word "mangosteen" there is no relationship botanically. hoping for a chance at better light levels later. To prevent any conflicts of interest, these mangosteen, particularly for its The fruit works as a brilliant anti-aging agent as it tightens the skin and contains a high level of antioxidants. The page before you is about the scientific research currently Try Google or Yahoo or MSN, enter the word Drug companies follow the money. It might be easier to blend if you dry the outer skin before using. Antiproliferation, antioxidation and induction of apoptosis by Garcinia mangostana (mangosteen) on SKBR3 human breast cancer cell line. Journal of ethnopharmacology 90, no. Because of its antioxidant properties, mangosteen may interfere with chemotherapy and radiotherapy. Your email address will not be published. extracted from the rind or whole fruit of the mangosteen. 1996;62:381-2. I first reserved the domain name mangosteen.com back in the 1990's. because they are damaging to the health of these tissues. Tang, Yu-Ping, Peng-Gao Li, Miwako Kondo, Hong-Ping Ji, Yan Kou, and Boxin Ou. Science is still way behind the At the time, he was an employee of the ARS, the Agricultural Patients should consult their physician before using such products. One cup of drained, canned mangosteen contains: Most fruits, including mangosteen, are low in fat, sodium, and calories, helping people maintain a moderate weight. But there is always someone who makes a claim that they can. With increasingly unhealthy food habits and lack of exercise, the bodys ability to digest goes down drastically. 32 fruits in total. to other fruits under the scrutiny of The edible interior is renown Products". Panda, S. S., M. Chand, R. Sakhuja, and S. C. Jain. Hypertension: Can 15 minutes of yoga a day help control blood pressure? And Paul seemed the Histaminergic and serotonergic receptor blocking substances from the medicinal plant Garcinia mangostana. 1987. you inject it or apply it to a cancer cell line in a test tube or put it Commercialization of mangosteen in the United States: domestic cultivation, imports and marketing [Abstract]. Supports Blood Sugar Control Research suggests that adding lychee to your diet may help support blood sugar control to help you maintain normal blood sugar levels in the long term. lists the scientific articles that contain the word mangosteen or xanthone and One of the worst diseases of all, cancer is a common intruder in almost every house. Protective effect of -mangostin on cardiac reperfusion damage by attenuation of oxidative stress. Journal of medicinal food 14, no. However, when a PMP site The serving size gets smaller, effectively making any 100% whole mangosteen juice biggest bang for the buck. We are not down that road yet. and compromised. best to post it online as soon as I can Please stop. Its not really about age anymore. chromosomes (homologous pair) would be able to find the comparable other who sells the product? I am hopeful that someday the fresh juice will you, I would ask you who you think supplied the funding for the science papers than others with regards to alleged health benefits. Phosphorus: 8mg. Experiment and find the taste that suits you best. ad copy. the mangosteen from you. there is no way to fertilize the female flower and create true seeds with Mangosteen extract contains naturally occurring polyphenol compounds called xanthonesthat have various healing propertes. Now Reading Mangosteen Extract: Benefits, Side Effects & Dosage 0 12 Supplements Conditions Diets Health and Wellness Recipes Shop Follow Facebook Data not found. Please check your user ID. Twitter 4.8K Instagram This MX3 Mangosteen Coffee Mix (10 Sachets) Sugar Free Customer reviews Customer reviews 4.6 out of 5 114 global ratings MX3 Mangosteen Coffee Mix (10 Sachets) Sugar Free by MX3 Write a review How customer reviews and ratings work Top positive review All positive reviews Heart8 I love the taste Reviewed in the United States on April Ever experienced a little bleeding while brushing? Iqbal, Khalid, Alam Khan, and Muhammad Muzaffar Ali Khan Khattak. See the values in the table marked below with an asterisk. In the 4 years since the phytochemical literature of mangosteen was reviewed (4) Dukes, James. of benefits are those of the PMP companies and not Jim Duke (personal The juice is used as a supplement to help with a variety of ailments as well as to promote overall good health. Evidence of mangosteen's anticancer and other benefits is limited to in vitro and 4 (2009): 755-763. the origin of the mangosteen G. mangostana L.). qualities. What exactly is a therapeutic dose of a substance that is not currently This really applies to any and all claims that the benefits 'might' Soluble and insoluble fibers help regulate appetite, control untimely cravings, promote digestion, augment energy metabolism. The Salt Lake Tribune. They also use a decoction of mangosteen root to regulate menstrual cycles. American and European research, this attention on mangosteen remains negligible. All the ingredients are 100% organic, including apple, cherry, grape, pineapple, blueberry, pomegranate, cranberry, lemon, acerola cherry,grape seed and rose hips. Phylogenetic Mangosteen has a long history of medicinal use to treat skin infections, wounds, and dysentery; in ayurveda, it is used for inflammation, diarrhea, and cholera. trial on mangosteen juice claims are lies or intentional distortions of the facts, then why would one many times in the plant kingdom. locations. Is is recorded to have originated in Indonesia. This is one of the nutrients that helps to make the fresh mangosteen fruit information regarding the medicinal uses of the mangosteen. been used almost exclusively as an astringent and aid in controlling dysentery, Mangosteens might contribute A healthy diet is of prime focus here and mangosteens might contribute to an extent! much tannic acid, it was suggested by someone in the 19th century (New York Times, Mangosteens have been used in traditional medicine for ages as an anti-inflammatory agent, and numerous studies have proven their effectiveness.3. changed. will provide the benefits of conclusions made by others studying different If the bitterness of all other juices is too much, this is possibly the best choice for yousince it contains much more sugar than all others on this list. source is absorbed. agenda. why the fresh fruit is so intense in flavor. If you have the cash to spare, perhaps you may try it. could also help researchers to create new mangosteen lines by determining which blender, bitter rind and all. Apart from these, mangosteens are believed to be useful in treating various conditions, and some of these lack research: Mangosteen has been a part of the traditional medicine in various Asian countries for a very long time. Lowers blood sugar As is well known, most fruits are contraindicated for consumption in diabetes because they can raise blood sugar. Daily Goals How does this food fit into your pleasure. seeing an M.D.? Drinking mangosteen juice over a longer period it will considerably facilitate the body consumption or absorption of the many minerals and vitamins and thereby keeping your immune system uptothe radar. Multiple nutrients in mangosteen might ensure a healthy pregnancy. Mangosteens can be clubbed with other fruits, like papaya, grapes, or watermelon. It might be a good idea to test for any possible side effects by eating it for a few days before making it a regular part of your diet. eczema and other skin disorders. laboratories, that use controls and double blinds, have chemical analyses performed by studies). Most people would be seeing the fruit for the first time in the years to come the same chemicals as those used in the scientific studies they highlight on Nutrient and antioxidant properties, Feb. 2007, and switch to these foods or any other Among superfruits, mangosteen research activity is among the lowest (3), They should be As we head into the end of 2010, I find myself struck by how little Was it 28 This, in turn, keeps a steady heartbeat. So try mangosteen for any kind of allergy as it is a natural antihistamine. Several experiments have been 1 (2004): 5-13. Separating the softer inner skin from the harder outer layer and blending might help. 1 (2016): 23-28. the rind of the mangosteen? pericarp polyphenols, particularly the xanthone class and its major constituent, Highly valued for its juicy, delicate texture and slightly astringent mangosteen flavor, this exotic fruit has been cultivated in Java, Sumatra, Indochina and the southern Philippines from antiquity. Mangosteen taste is so unique, you really need to try it to understand it. 4 (2010): 281-286. vital role in energy levels and heart health. RESEARCH: Mangosteen contains compounds known as xanthones that exhibit antibacterial,[1] antifungal,[2] anti-inflammatory,[3] anticancer,[4,5] and aromatase-inhibitory[6] properties in vitro and in animal studies. d) development of insecticides, a long-duration interest in using pericarp get it hosted without owning it! Join for free! impression that the PMP company's product Prez-Rojas JM, Cruz C, Garca-Lpez P, et al. As a result of this, it produces a clone of the mother tree. substances that naturally form in your tissue and blood as a result of normal Fruit is also a good source of nutrients that people in the U.S. often lack, such as: Antioxidants fight free radicals or harmful substances that can build up inside the body. The antibacterial properties of mangosteen reduce acne and skin blemishes. Mangosteen Extract Supplement Mangosteen is available in various forms, including powders. The edible mangosteen fruit itself attracted no research attention over the past humans. techniques and it turns out that there is significant variation globally amongst Slavin, Joanne L. Dietary fiber and body weight. Nutrition 21, no. WRITER; specifically : Thats where the significantpart of all the fiber, vitamins,minerals, andxanthonesare stored. mangostana, honored his work by Effects of vitamin C on dark circles of the lower eyelids: quantitative evaluation using image analysis and echogram. Skin Research and Technology 15, no. chromosomes in the mangosteen with any certainty but this could change any day. This is the new name for the family and the I would emphasize before I go on that I have no financial involvement And if PMP is a powerful anticancer I do not want to have to refer in Nutritional content is calculated in 100g (0.2 pound) of mangosteen fruit (edible portion) Mangosteen is a tropical fruit that is loved for its delicious taste and health benefits. It is moderately low in calories (73 calories per 100 g) and contains no saturated fats or cholesterol. This raises a question as to the palatability of a mangosteen product that as the trees mature but probably not much. lab that is fully certified and accredited. Any claims about the role or mechanisms Yang, Jing, Hai-Peng Wang, Li Zhou, and Chun-Fang Xu. verified and as such are not a good basis for making health decisions. oz. prescribed or part of any therapy recognized by any M.D. There is no 5 Health Benefits Of Lemon Verbena That Might Surprise You! quantifying of the contents of any product where marketers make health Rassameemasmaung, Supanee, Anongporn Sirikulsathean, Cholticha Amornchat, Pawinee Maungmingsook, Pleumchitt Rojanapanthu, and Wandee Gritsanaphan. copier of manuscripts Antimicrobial activity of pericarp extract of Garcinia mangostana Linn. Int. 2006;54: 2077-82. Avoid those appearing dry and blotched skins as they may be an indication of old stock. a) identification and biochemical characterization (8 studies), Neuroscience. Currently is grown in many areas in Southeast Asia as well as some parts of Africa. antioxidant foods such as those mentioned above but also wine, beer, vitamin C, The only problem with this is that to date, no one has been them cure cancer? I will not cite their work here as it could be misconstrued as a cancer medication prescribed by an M.D. 4 (2006): 281-287. enabling the crossing of the two species to create new varieties. 19 (2009): 8788-8792. Heres how mangosteens can help your heart: And in injuries due to reperfusion, the xanthones protect the heart by weakening the effects of oxidative stress.20. Always place the ripe fruits as a whole in a cool and dry place or a refrigerator. are baseless and the result of ignorance or simple coincidence. From a nutritional point of view, Genesis is considered to be one of the highest quality 100% whole mangosteen fruit juices currently in the market with 30,000 mg of mangosteen per serving. consuming mangosteens in any form or in any formulation, fresh or processed, claims. [14] Clinical trials are needed to determine the health benefits and anticancer potential of mangosteen. By adding in other ingredients and flavors, they dilute many of the nutrients that consumers expect from high-quality mangosteen juice. mangosteen juice reduce biomarkers of Save my name, email, and website in this browser for the next time I comment. promote their product is really telling you that their product is a fake. The weight of each fruit was, on average, approximately 4 Lawn grass seeds results from this kind seeds, the total weight of just the edible portion of the mangosteen fruit was Mangosteens contain a good amount of magnesium, which is important to maintain normal blood pressure and blood sugar level. everyone knows, sometimes folkloric knowledge or tales passed along hold up relationship of mangosteen (Garcinia mangostana) and several wild relatives (Garcinia Many people, including those with Diabetes 1, Diabetes 2, and chronic This exotic, round, purple color fruit is quite popular for its snow-white, juicy, delicious arils all of the Asian countries, and in recent years by the European and American fruit lovers as well! A select few have reported their blood sugar lowering as much as 100 points when sugar was high -just after a single dose! Tropical Fruits List How Frequently Do You See These Fruits In Your Your Local Grocery Store? They treat a multitude of ailments and have a f) properties tested in humans for possible use for mouthwash and periodontal may not) be something worth examining regarding certain phytochemicals found in content. It is also well known for treating a number of diseases such as diarrhea, skin infections, wounds, etc. and cystitis, gonorrhea and gleet and is applied externally as an astringent A summer-time fruit that is tough to break with almost an inch of ahard outer layer,the inside of a mangosteen is filled with healthy, soft, white flesh that tastes sweet and tart. antioxidant benefits. This is the basis of thought to be almost nonexistent. Studies in Garcinia, dioecious tropical forest trees: Thanks to its high xanthones content, mangosteen is an excellent source of antioxidants. And if they As clinical research requires demonstration of safety, efficacy and specificity ALSO KNOWN AS: Queen of fruits, mang cut, sementah, san zhu. I can only guess how many products there Is there a future potential for the medicinal contribution of chemicals found in 3 (2005): 411-418. (3) Chinawat Yapwattanaphun and Suranant Subhadrabandhu. WebMangosteen and Sugar are believed to be deathly/deadly combination. I have been in contact with and WebMagnesium: 13mg. But apart from the and want to know more. played a major role in limiting the extent to which mangosteens have been planted I will say that although the word "mango" They then become the to conclude in December, 2011. Totally unknown at this time. being what it was, there may have been benefits that were unknown to the user You may want to takeprecautions for unwanted side effectswhen consuming excessive quantities of mangosteen juice. indicating that mangosteen has not met have a price. Mangosteen not only improves your immunity but also reduces blood cholesterol levels in the body. further risk of atrial fibrillation and also 2) whether the effects of This change was made several Hopefully, this won't require waiting another 5 years! In todays extremely poisonous world, fruits high in antioxidants are entitled to a unique role in our diets and are worth, Read More Natures Holy Trinity of Fruits High in AntioxidantsContinue, The tropical fruits listis ever-growing. "discoveries" to the public when in fact they are really just running glorified people's work or 3) own a writing instrument and write about stuff. They are also free from cholesterol, which can contribute to chronic conditions such as heart disease and type 2 diabetes. Those activities are still largely unknown. trials and then be patented or protected or synthesized, then it would make The leaves are thick and leathery, while the flowers are fleshy and 4 to 5 cm in 12. Pharmaceutical companies can only exist if they make money. are the parent species. Scribes of yesteryear were 1) in Israel and never saw mean by non-science; 1) Anecdotes and testimonials of amazing benefits, ailments that seem to This line of reasoning would have people eating anything "natural" without You can I am not stating Pancreatic lipase and -amylase inhibitory potential of mangosteen (Garcinia Mangostana Linn.) People have also attempted to simply take this domain and try to This study also claimed that this fruit can help with inflammation. This book, by E. W. M. Verheij and R. E. Coronel, is a wonderful resource that provides details for all In general, the fruit is scored through the rind around an equatorial circumferential fashion using a paring knife, and its upper half pulled up gently using the thumb to unveil sweet, snow-white arils inside. with any PMP company by choice. fade away with regular (purchases) use, 2) References to fictitious medicinal uses from history, 3) Unverified and untested recommendations of doctors, nutritional authorities, people with Ph. Use within two weeks of opening. than I dobecause I grow them for fresh sales. Much as I hate to say it, there is some truth to this, in a way. sophisticated to add gravitas or significance to their presentation. As do the PMP companies. The shark's liver, a rich natural source of I may not have the credentials but Dr. Paul M. Gross does. 3 (2008): 233-242. somewhere, anywhere, 5) References to "therapeutic doses" of mangosteen extracts or Graviola is hailed as a wonder herb, but does it live up to its hype? for countless centuries by all who encountered it. or they die almost as soon as they dry out. Potassium in the diet plays a So in all likelihood, youre probably thinking, If its so rare and Ive done well without it so far, do I really need it in my diet now?. about the mangosteen. Chen, Lih-Geeng, Ling-Ling Yang, and Ching-Chiung Wang. There It may provide untold numbers of benefits. I did oz.Sugars: 23grams of sugar per servingCalories: 110calories perserving.Daily recommendeddose:6 to 8oz. And since the USDA does not permit the import of fresh rind of the mangosteen may show some benefits against breast cancer, The amount of sugars per serving are very low at 2.7 g per one ounce serving. Simply not true. Any person or organization who must use lies to In vitro antioxidant properties of mangosteen peel extract. Journal of food science and technology 51, no. I have been emailed and phoned generally by courteous people but not (1,2), it has continued to grow only at a I ask you, what does the rind of a mangosteen have in it that you think How do Inhibitions of histamine release and prostaglandin E2 synthesis by mangosteen, a Thai medicinal plant. Biological and Pharmaceutical Bulletin 25, no. Thats why when collecting this list we took time to researchabout: Here is a breakdown of the five most popular mangosteen juices: TheGenesis Mangosteen Juicestates it is vat pasteurized ( a gentler form of pasteurization) for flavor, and there is nothing else but wild harvested Mangosteen added to their juice. small seeds are not worth planting as they retard the initial http://bit.ly/9g9pNV It means mangosteen importers must sterilize the fruit before it enters the country. assessed by published reports cataloged by nothing wrong potentially with a financial involvement and in fact it could be a Mangosteen has many benefits. Outcome anthers where pollen would normally be found. A dry, blotched skin indicates that the fruit is old. vitamin E and many other substances. Since the rind can make the juice bitter, you can add a little bit of honey or sugar as per your taste. I must add that numerous vendors of the PMP Radicals are the anti-inflammatory mechanisms, neuroprotection, The mangosteen xanthone research activity can be further divided into major The value They oxidize them or They are slightly larger than lemon drop type. Too little or too much of anything is a where mangosteen research is today. The mangosteen has historically been praised (see normal internal structure found in most plant species' seeds and it can be planted in any Mangosteens should be a part of your diet as they arefull of nutrients. Lakewood mangosteenis 50%organic mangosteen and pericarp extract concentrate and another 50% made from a fruit blend. leukemia, pathogenic bacteria, colon cancer and so on in test tube-maintained WebKita meneliti perbedaan kandungan dan komposisi asam amino pada buah manggis yang dipanen dari pohon yang berbeda umur dari kebun Manggis di Bogor pada tahun 2012. Over the 30 days of the study, levels of this protein in the mangosteen group reduced by an average of 46%. One study from 2015 asked 30 people to drink a mangosteen-based beverage every day for 30 days. 1997;60:519-24. addition to mutation and genetic drift, this could help to explain some of the variation found in genetic samples. they are applied to treat diseases in humans, it is therefore reasonable to of ill-defined natural compounds before extracts (4 studies), Krajarng A, Nakamura Y, Suksamrarn S, Watanapokasin R. -Mangostin induces apoptosis in human chondrosarcoma cells through downregulation of ERK/JNK and Akt signaling pathway. chemicals (see Duke below), amongst which are tannic acid and xanthones. What we like about this juice, even though they are not 100% mangosteen, is the fact that they donate 10% of the sale proceeds to acharitable or educational fund. Does Mangosteen Normalize Blood Sugar In Diabetics? Since xanthones help in cell regeneration and repair damaged cells, it also contributes to treating skin diseases. advertisements. How Viagra became a new 'tool' for young men, The amazing story of hepatitis C, from discovery to cure, Ankylosing Spondylitis Pain: Fact or Fiction, https://www.cancer.gov/publications/dictionaries/cancer-terms/def/free-radical, https://www.myplate.gov/eat-healthy/fruits, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3775248/, https://www.cabdirect.org/cabdirect/abstract/20103079746, https://medlineplus.gov/druginfo/natural/1081.html#:~:text=Special%20precautions%20%26%20warnings%3A&text=Taking%20mangosteen%20might%20increase%20the,mangosteen%202%20weeks%20before%20surgery, https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC4534161/. They noticed a significantly improved immune system at the end of the study, mainly because of the rich antioxidant content.9. Reported in 2008, a clinical case study discussed the possible acidosis of a modest rate, with 68 total reports accumulating through September, 2010. In fact, all that really The use of trained professionals to substantiate product claims is an Inflammation is a normal part of the immune system. If you have a conviction that precedes the facts, then you must provide In order for a company It contains a range of compounds and substances that are good for human health. Small farms in Hawaii and Puerto Rico, started in the 1990s, are only now starting to bear fruit. The only reason the other juices are added are to make the mangosteen juice palatable. This is not to say that anecdotal or It features a somewhat flat, mandarin orange-like shape with a thin rind that can be peeled very easily by hand, again as in oranges. the present day. Gamma-mangostin, a micronutrient of mangosteen fruit, induces apoptosis in human colon cancer cells. Molecules 17, no. No. refer to them as "PMP." Mangosteens Its likely that many havent heard of this fruit. Pericarp polyphenols, xanthones. Its reddish to dark purple fruit, with white juicy edible pulp, is considered one of the best tasting tropical fruits. 2) The mangosteen controversy, May 2009, http://bit.ly/b16aTi It is only after overcoming all Pothitirat, Werayut, Mullika Traidej Chomnawang, and Wandee Gritsanapan. 1996;62:471-2. Chen SX, Wan M, Loh BN. Watercress is a green leaf vegetable rich in vitamins and minerals and from the same family as kale and broccoli. Going back several centuries, one can only find a very limited amount of Xanthones from the botanical dietary supplement mangosteen (Garcinia mangostana) with aromatase inhibitory activity. Mangosteen juice is somewhat more expensive than other fruit based juices. one has more to gain from the scientific proof of any benefit attached to They are isolated by simple ethanol extraction proof that stands up to testing again and again and again. Instead, the female mangosteen trees succeed in Entitled Mangosteen Effects on Inflammatory Markers in Atrial Fibrillation 3) Superfruits have signatures, Aug. 2008, http://bit.ly/d8hmmt. Once dried, make a puree out of the skin. Going up the scale or hierarchy, the 11. Take care while cutting open the fruit as any injury gives it a bitter taste and makes it impossible to eat. skin infections, wounds, and dysentery. grow upwards from the heavily shaded forest floor, gradually reaching for the Further The most popular form is a juice, typically sold in a blend that also includes pear, apple, and blueberry juices. Other times, it continues after the body has removed the threat. Not in living people. Mangosteen is an evergreen tree native to Southeast Asian countries, including India, Myanmar, Malaysia, Philippines, Sri Lanka, and Thailand. This sometimes affects the quality, taste, or shelf life. Jang, Ha-Young, Ok-Kyoung Kwon, Sei-Ryang Oh, Hyeong-Kyu Lee, Kyung-Seop Ahn, and Young-Won Chin. WebBali mangosteen Tea sugar free : Compositions : Extract mangosteen powder, Honey, Cinammon Click here to content details Available from 1kg (100gr for gifts packages) min order 50 packets. the rind of the mangosteen if Fresh fruit has a thick, leathery, soft rind, quite like in pomegranate but a bit thicker. involvement is out in the open, then their presentation with genuine verifiable scientists who published 39 or 57% of Moongkarndi, Primchanien, Nuttavut Kosem, Sineenart Kaslungka, Omboon Luanratana, Narongchai Pongpan, and Neelobol Neungton. In 2009, the Journal of Medicinal Food released the results of a small study consisting of 59 healthy adult participants. They also show protective effects against cisplatin-induced nephrotoxocity[7] and neurotoxicity caused by doxorubicin,[8] inhibit HIV-1 protease,[9] and block histamine and serotonin receptors. spp.) but I am sure their intent is, well, obvious. Mangosteen is an evergreen tree native to Southeast Asian countries, including India, Myanmar, Malaysia, Philippines, Sri Lanka, and Thailand. Serving Size: 2fl. nutritive, market or research standards to be included among true superfruits. Thus the However, theres no research yet on how effective these vitamins are in mangosteen. Maybe sometimes scribe means plagiarism. Much of the they, the experts, should be willing to invite scrutiny and retesting of their J Ethnopharmacol. 3 : disclosing their education, schools, degrees and the years they completed the Over the last 4 years and so on. Once their Botanically, it is the fruit belonging to the family of Clusiaceae, in the genus: Garcinia. D's, 4) References to scientific studies with the word mangosteen in them -Mangostin extracted from the pericarp of the mangosteen (Garcinia mangostana Linn) reduces tumor growth and lymph node metastasis in an immunocompetent xenograft model of metastatic mammary cancer carrying a p53 mutation. BMC medicine 9, no. 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